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A hypothesis: FN3KRP (Fructosamine-3-Kinase-Related Protein) phosphorylates intermediates downstream from fructosamines in the pathway leading from glucose to glucosepane. [version 1; peer review: awaiting peer review]

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When:
May 12, 2026 ยท 10:20 AM
Source:
F1000Research

Fructosamine-3-kinase is a deglycating enzyme that reverses the glycation reaction by phosphorylating the first stable Maillard intermediate, fructosamine, to fructosamine-3-phosphate, thereby causing decomposition of that glycation adduct. In this paper I propose that a close homolog of that kinase, fructosamine-3-phosphate-related protein, phosphorylates 3-ketosamine, a Maillard intermediate downstream from fructosamine, to 3-ketosamine-4-phosphate. This phosphorylation causes decomposition of

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