Event Dime
A detailed methodology for developing and applying a 3D polyHIPE scaffold to model myeloma cell dormancy in vitro [version 1; peer review: awaiting peer review]
Events
- When:
- May 14, 2026 ยท 12:55 PM
- Source:
- F1000Research
Background Multiple myeloma is characterised by the outgrowth of malignant plasma cells in the bone marrow (BM). Disease relapse is driven by the reactivation of dormant myeloma cells (DMCs) that interact with osteoblastic lineage cells within the BM to evade therapy. Current two-dimensional (2D) in vitro culture systems lack the physiological and spatial complexity to replicate the BM microenvironment, while animal models offer limited control over microenvironmental components for systematic i